Endocrine Abstracts

In addition to their role in cellular energy metabolism, mitochondria are now recognised as central players in cell death. Critical to this role is the mitochondrial permeability transition pore (MPTP) whose opening uncouples mitochondria, preventing them from providing for the energy needs of the cell leading to necrotic cell death. MPTP opening is important in the injury to the heart and brain that follows an ischaemic episode such as a heart attack or stroke and agents that...